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KPV (Lys-Pro-Val)

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KPV is a research material associated with peptide signaling research. Intended for laboratory research and analytical use only; not for human or veterinary use.

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Molecular Structure Explorer

KPV

Structure of the compound on this page.

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Molecular structure of KPV

Data from PubChem (NCBI) or a reviewed manual entry, shown only after review. 3D models are computed conformers, not experimental structures. Browsing does not change the product, option or cart. For laboratory research use only.

Product Details

KPV (Lys-Pro-Val) – Research Grade

KPV (Lys-Pro-Val) from Cleared Peptides is a research-grade compound supplied for laboratory and analytical investigation. Every lot is third-party tested, and the batch Certificate of Analysis is published before sale. Specifications, CAS number and molecular formula are listed below.

Research use only. KPV (Lys-Pro-Val) is supplied for laboratory research. It is not a drug, food, cosmetic, or dietary supplement. It is not FDA-approved. It is not for human or veterinary administration. This page does not give a dose or a method of administration. A study cited on this page describes that study’s own test article. It does not make this lot an approved medicine. To check a fact, open the PubMed or DOI link, confirm the authors and year, and match the paper’s compound name, CAS number, or sequence to the specification table. The full method is on the research desk page. Identity and purity for a lot are only what that lot’s certificate of analysis reports. An HPLC percentage is not a sterility result and not an endotoxin result unless the certificate prints those tests.

KPV Specifications

CompoundKPV
SynonymsLys-Pro-Val; α-MSH (11-13)
CAS Number67727-97-3
PubChem CID125672
Molecular FormulaC16H30N4O4
Molecular Weight342.4 g/mol
Sequence / StructureLys-Pro-Val
FormLyophilized (freeze-dried) powder
Purity≥99% by HPLC (verified per batch – see COA)
StorageStore at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening.

KPV in Published Research

KPV is the tripeptide Lys-Pro-Val, corresponding to the C-terminal residues 11–13 of α-melanocyte-stimulating hormone (α-MSH). Its small size makes it a convenient tool compound for peptide transport and signaling studies.

Published in-vitro research has examined KPV in epithelial and immune-cell models, including NF-κB and MAPK inflammatory-signaling assays and PepT1-mediated peptide uptake.

This summary describes published laboratory research only and makes no claim about effects in humans or animals.

Purity Testing & Certificate of Analysis

Each lot of KPV is analyzed by an independent laboratory, with identity and purity (or composition, for multi-component preparations) reported on a lot-specific Certificate of Analysis. View current results on our COA page.

Storage & Laboratory Handling

Store at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening. Minimize freeze–thaw cycles and handle according to your institution’s chemical-hygiene procedures.

Frequently Asked Questions

Is KPV third-party tested?

Yes. Every lot of KPV is tested by an independent laboratory for identity and purity, and the batch Certificate of Analysis is published on our COA page.

Can I see the KPV Certificate of Analysis before ordering?

Yes. Lot-specific COAs are posted on our COA page so you can review analytical data before purchase.

What does Research Use Only (RUO) mean?

RUO products are supplied solely for laboratory and analytical research. They are not medicines, are not for human or veterinary use, and no dosing or administration information is provided.

How should KPV be stored?

Store at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening.

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Research Guides

Learn more: KPV research guide

Written by the Cleared Peptides Research Desk, the editorial desk of Cleared Wellness Group LLC. This is not a personal profile of a physician or a scientist, and it is not a fictional author. The checking method is public on the research desk page. Last reviewed October 2026.

KPV research note: three residues of α-MSH, not the whole hormone

Research use only. This KPV material is the tripeptide Lys-Pro-Val for laboratory research, CAS 67727-97-3. It is not α-MSH, it is not a drug, and it is not for human or veterinary administration.

α-MSH is a 13-residue peptide cut from pro-opiomelanocortin. KPV is residues 11–13, the C-terminal tripeptide. The catalog mass is about 342.4 g/mol, formula C16H30N4O4. A paper that injected or applied full-length α-MSH is background for the parent hormone. It is evidence about KPV only in the experiments that actually used Lys-Pro-Val.

Brzoska, Luger, Maaser, and colleagues (Endocrine Reviews, 2008) review α-MSH and the related tripeptides, including anti-inflammatory work in cells and in animal models, melanocortin receptors, and pathways such as NF-κB. The article is a review with a therapeutic outlook in its title. That outlook is the authors’ perspective. It is not a finding that this vial treats a disease, and this page will not repeat disease claims as if they were lot specifications. The useful instruction for a reader is narrower: open the review and see which cited experiment used the tripeptide rather than the 13-mer. PubMed 18612139, DOI 10.1210/er.2007-0027.

Analytically, a tripeptide this small and this polar is easy to lose in the solvent front of a reversed-phase method. A purity claim needs a method that retains it, usually with ion pairing, and a mass that matches 342.4 rather than the mass of intact α-MSH.

How to verify this note

  1. Match Lys-Pro-Val and CAS 67727-97-3. Do not match a 13-residue α-MSH mass and call it KPV.
  2. In Brzoska 2008, separate tripeptide experiments from full-hormone experiments before quoting a result.
  3. Keep the certificate as the only lot record.

Selected References

Peer-reviewed literature on KPV (Lys-Pro-Val), listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.

  1. Catania A, et al. The neuropeptide alpha-MSH in host defense. Ann N Y Acad Sci. 2000;917:227-31. PubMed 11268348 · DOI
  2. Ichiyama T, et al. The neuroimmunomodulatory peptide alpha-MSH. Ann N Y Acad Sci. 2000;917:221-6. PubMed 11268347 · DOI

Related Research Compounds

Research Use Only

For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not FDA-approved, and is not intended for human or veterinary use or for the diagnosis, treatment, cure, mitigation or prevention of any disease. No dosing, administration or therapeutic information is provided. Sold only to qualified researchers; the purchaser is responsible for safe handling and compliance with all applicable laws and institutional requirements.

Certificate of Analysis (COA)

Choose a report to see its lab results, purity and measured amount. Match the MG amount and lot number to your product.

KPV (Lys-Pro-Val)

Reinstoff Labs — 10 MGRL-2026-000806 · Lot # US26KPV1001PASSLatestView details ⌄
Laboratory report · Reinstoff Labs

Tap this certificate to view the full certificate.

Certificate of Analysis issued by Reinstoff Labs. Batch ID: US26KPV1001 · HPLC purity: 99.6% · Report code: RL-2026-000806

Reinstoff Labsreinstofflabs.de
REPORT NUMBERRL-2026-000806
SAMPLE

KPV

CLEARED PEPTIDES · Lot US26KPV1001

PASS
99.6%PURITY BY HPLC
Labeled amount
10.0 mg
Identity · LC-MS
Confirmed
Analysis completed
KPV
SterilityNo growth✓ PASS
EndotoxinsWithin specification≤ 5.0 EU/mL✓ PASS
Fentanyl screeningNot detected✓ PASS

Findings relate to the tested sample and recorded method. See the full report.

Issued by Reinstoff Labs. For research use only.

Certificate of AnalysisLot # PPA-WL-KPV10-P000704July 27, 2026KPVV-compatible PASSView details

PACIFIC COAST BIOLOGICS

KPV (Lys-Pro-Val) · PPA-WL-KPV10-P000704

PASS
99.2%Purity by HPLC
Lot number
PPA-WL-KPV10-P000704
Tested
July 27, 2026
Measured amount
12.21 MG

Read the full certificate for test methods, specifications and results.

Certificate preview
View the certificate
Certificate of Analysis — 9.2 MGLot # Q6NV98MJune 8, 2026 PASSView details

KRAUSE ANALYTICAL

KPV (Lys-Pro-Val) · Q6NV98M

PASS
99.1%Purity by HPLC
Lot number
Q6NV98M
Tested
June 8, 2027
Labeled amount
9.2 MG
Measured amount
9.02 MG

Read the full certificate for test methods, specifications and results.

Certificate preview
View the certificate

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