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AICAR

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AICAR is a research material associated with cell & molecular biology research. Intended for laboratory research and analytical use only; not for human or veterinary use.

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SKU: AICAR-A Category: Tag: Brand:

Molecular Structure Explorer

AICAR

Structure of the compound on this page.

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Molecular structure of AICAR

Data from PubChem (NCBI) or a reviewed manual entry, shown only after review. 3D models are computed conformers, not experimental structures. Browsing does not change the product, option or cart. For laboratory research use only.

Product Details

AICAR – Research Grade

AICAR from Cleared Peptides is a research-grade compound supplied for laboratory and analytical investigation. Every lot is third-party tested, and the batch Certificate of Analysis is published before sale. Specifications, CAS number and molecular formula are listed below.

Research use only. AICAR is supplied for laboratory research. It is not a drug, food, cosmetic, or dietary supplement. It is not FDA-approved. It is not for human or veterinary administration. This page does not give a dose or a method of administration. A study cited on this page describes that study’s own test article. It does not make this lot an approved medicine. To check a fact, open the PubMed or DOI link, confirm the authors and year, and match the paper’s compound name, CAS number, or sequence to the specification table. The full method is on the research desk page. Identity and purity for a lot are only what that lot’s certificate of analysis reports. An HPLC percentage is not a sterility result and not an endotoxin result unless the certificate prints those tests.

AICAR Specifications

CompoundAICAR
SynonymsAcadesine; 5-Aminoimidazole-4-carboxamide ribonucleoside
CAS Number2627-69-2
PubChem CID17513
Molecular FormulaC9H14N4O5
Molecular Weight258.2 g/mol
Sequence / StructureNucleoside (not a peptide)
FormPowder
Purity≥99% by HPLC (verified per batch – see COA)
StorageStore at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening.

AICAR in Laboratory Research

AICAR (5-aminoimidazole-4-carboxamide ribonucleoside, acadesine) is a cell-permeable nucleoside that is phosphorylated intracellularly to ZMP, an AMP analog.

It is one of the most widely used pharmacological tools for activating AMP-activated protein kinase (AMPK) in cell-culture and biochemical studies.

This summary describes published laboratory research only and makes no claim about effects in humans or animals.

Purity Testing & Certificate of Analysis

Each lot of AICAR is analyzed by an independent laboratory, with identity and purity (or composition, for multi-component preparations) reported on a lot-specific Certificate of Analysis. View current results on our COA page.

Storage & Laboratory Handling

Store at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening. Minimize freeze–thaw cycles and handle according to your institution’s chemical-hygiene procedures.

Frequently Asked Questions

Is AICAR third-party tested?

Yes. Every lot of AICAR is tested by an independent laboratory for identity and purity, and the batch Certificate of Analysis is published on our COA page.

Can I see the AICAR Certificate of Analysis before ordering?

Yes. Lot-specific COAs are posted on our COA page so you can review analytical data before purchase.

What does Research Use Only (RUO) mean?

RUO products are supplied solely for laboratory and analytical research. They are not medicines, are not for human or veterinary use, and no dosing or administration information is provided.

How should AICAR be stored?

Store at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening.

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Selected References

Peer-reviewed literature on AICAR, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.

  1. Višnjić D, et al. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells. 2021;10(5). PubMed 34064363 · DOI
  2. Verma P, et al. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis. FEBS J. 2017;284(24):4233-4261. PubMed 29063699 · DOI

Related Research Compounds

Research Use Only

For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not FDA-approved, and is not intended for human or veterinary use or for the diagnosis, treatment, cure, mitigation or prevention of any disease. No dosing, administration or therapeutic information is provided. Sold only to qualified researchers; the purchaser is responsible for safe handling and compliance with all applicable laws and institutional requirements.

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