Molecular Structure Explorer
SLU-PP-332
Structure of the compound covered in this guide.
Last reviewed: October 2026 · Cleared Peptides research team
Research use only. SLU-PP-332: Research Guide to the ERR Agonist is supplied for laboratory research. It is not a drug, food, cosmetic, or dietary supplement. It is not FDA-approved. It is not for human or veterinary administration. This page does not give a dose or a method of administration. A study cited on this page describes that study’s own test article. It does not make this lot an approved medicine. To check a fact, open the PubMed or DOI link, confirm the authors and year, and match the paper’s compound name, CAS number, or sequence to the specification table. The full method is on the research desk page. Identity and purity for a lot are only what that lot’s certificate of analysis reports. An HPLC percentage is not a sterility result and not an endotoxin result unless the certificate prints those tests.
SLU-PP-332 is a synthetic small molecule developed at Saint Louis University as an agonist of the estrogen-related receptors ERRα, ERRβ and ERRγ — orphan nuclear receptors that regulate genes involved in mitochondrial biogenesis and oxidative metabolism.
SLU-PP-332 Structure and Identifiers
| Name | SLU-PP-332 |
|---|---|
| CAS number | 303760-60-3 |
| PubChem CID | 5338394 |
| Molecular formula | C18H14N2O2 |
| Molecular weight | ≈290.3 g/mol |
| Type | Small molecule (not a peptide) |
| Form | Powder |
Estrogen-Related Receptors
Despite their name, ERRs do not bind estrogen. They are constitutively active nuclear receptors that partner with the co-activator PGC-1α. Synthetic agonists such as SLU-PP-332 are used to probe ERR-driven transcription in cell models.
Published In-Vitro Research Areas
- ERR reporter and target-gene expression assays
- Mitochondrial-biogenesis studies in muscle-cell cultures
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of SLU-PP-332 supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store SLU-PP-332 sealed at −20 °C, dry and protected from light. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Analytical testing notes for SLU-PP-332
SLU-PP-332 is identified in this guide as CAS 303760-60-3, formula C18H14N2O2, listed mass ≈290.3 g/mol. An identity test compares a measurement with those values. A mass spectrum is the usual measurement for a peptide. FTIR, when a certificate uses it, is a supporting infrared fingerprint and is less specific for closely related sequences.
SLU-PP-332 is not a peptide. Identity and purity may be chromatographic (HPLC or GC) or spectroscopic, depending on the method named on the certificate. The peptide-specific notes below — sequence mass, 214 nm peptide-bond detection, and net peptide content — should not be assumed. Sterility and endotoxin still apply only when those lines are on the report.
Read the method named on the certificate before treating a purity percentage as an HPLC area-percent result. Small molecules in this library may be assessed by HPLC, gas chromatography, or spectroscopy. The instrument named on the report is the one that applies. A purity result still does not measure sterility, endotoxin, or a labeled fill weight.
A sterility test and an endotoxin test are not included in a chemical purity result. The compendial sterility test is a culture method (USP <71>): membrane filtration or direct inoculation into fluid thioglycollate medium and soybean-casein digest medium, incubated for 14 days. A PCR sterility screen uses a thermal cycler to detect microbial DNA and is a different method. The endotoxin test (USP <85> LAL, or USP <86> recombinant Factor C) reports endotoxin units with an incubating reader or a cartridge reader. Use a result only when that method is printed on the lot certificate. One published example in this catalog states that the report does not cover microbial contamination or endotoxins. The full description of equipment, standards, and how US laboratory accreditation works is in peptide analytical testing. Lot records are on the COA page.
Frequently Asked Questions
Does SLU-PP-332 bind the estrogen receptor?
No. It targets the estrogen-related receptors (ERRs), which are distinct from estrogen receptors.
Is SLU-PP-332 for human use?
No. Cleared Peptides supplies SLU-PP-332 for laboratory research use only; it is not for human or veterinary use.
Selected References
Billon C, et al. Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(4):756-771. Cited as the chemical-biology report that identifies SLU-PP-332 as a synthetic ligand of the estrogen-related receptors in cell assays, with the highest reported potency at ERRα. Outcome wording in the paper title is not repeated as a claim on this site.
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
