SS-31 (Elamipretide)

SS-31 (Elamipretide) – Research Grade

SS-31 (Elamipretide) from Cleared Peptides is a research-grade compound supplied for laboratory and analytical investigation. Every lot is third-party tested, and the batch Certificate of Analysis is published before sale. Specifications, CAS number and molecular formula are listed below.

Research use only. SS-31 (Elamipretide) is supplied for laboratory research. It is not a drug, food, cosmetic, or dietary supplement. It is not FDA-approved. It is not for human or veterinary administration. This page does not give a dose or a method of administration. A study cited on this page describes that study’s own test article. It does not make this lot an approved medicine. To check a fact, open the PubMed or DOI link, confirm the authors and year, and match the paper’s compound name, CAS number, or sequence to the specification table. The full method is on the research desk page. Identity and purity for a lot are only what that lot’s certificate of analysis reports. An HPLC percentage is not a sterility result and not an endotoxin result unless the certificate prints those tests.

SS-31 Specifications

SS-31 (Elamipretide) in Published Research

SS-31 (elamipretide, MTP-131) is a synthetic aromatic-cationic tetrapeptide (D-Arg-Dmt-Lys-Phe-NH2) that associates with cardiolipin in the inner mitochondrial membrane.

It is used in mitochondrial biochemistry research to study cardiolipin interactions, electron-transport-chain function and reactive-oxygen-species production in isolated mitochondria and cell models.

This summary describes published laboratory research only and makes no claim about effects in humans or animals.

Purity Testing & Certificate of Analysis

Each lot of SS-31 is analyzed by an independent laboratory, with identity and purity (or composition, for multi-component preparations) reported on a lot-specific Certificate of Analysis. View current results on our COA page.

Storage & Laboratory Handling

Store at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening. Minimize freeze–thaw cycles and handle according to your institution’s chemical-hygiene procedures.

Frequently Asked Questions

What is the difference between SS-31 and elamipretide?

They are the same compound: SS-31 is the research code and elamipretide is the nonproprietary name (CAS 736992-21-5).

Is SS-31 third-party tested?

Yes. Every lot of SS-31 is tested by an independent laboratory for identity and purity, and the batch Certificate of Analysis is published on our COA page.

Can I see the SS-31 Certificate of Analysis before ordering?

Yes. Lot-specific COAs are posted on our COA page so you can review analytical data before purchase.

What does Research Use Only (RUO) mean?

RUO products are supplied solely for laboratory and analytical research. They are not medicines, are not for human or veterinary use, and no dosing or administration information is provided.

How should SS-31 be stored?

Store at −20 °C, sealed, dry and protected from light. Allow vial to reach room temperature before opening.

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Research Guides

Learn more: SS-31 (elamipretide) research guide · MOTS-c research guide

Written by the Cleared Peptides Research Desk, the editorial desk of Cleared Wellness Group LLC. This is not a personal profile of a physician or a scientist, and it is not a fictional author. The checking method is public on the research desk page. Last reviewed October 2026.

SS-31 research note: a cardiolipin-targeted tetrapeptide

Research use only. This SS-31 material, also called elamipretide or MTP-131, is for laboratory research, CAS 736992-21-5. It is not an approved drug on the strength of this page, and this note does not give a dose.

Class, then the named compound

Zhao, Zhao, Wu, and colleagues (Journal of Biological Chemistry, 2004) described cell-permeable peptide antioxidants aimed at the inner mitochondrial membrane. The motif is alternating aromatic and basic residues, with dimethyltyrosine as the scavenger. They report that the peptides concentrate at that membrane and reduce oxidative injury in the cell and mitochondrial preparations they used. PubMed 15178689, DOI 10.1074/jbc.M402999200. Use that paper for the class. Confirm in the full text which analogue code is which before assigning a sentence to SS-31 specifically.

Birk, Liu, Soong, and colleagues (Journal of the American Society of Nephrology, 2013) name SS-31 and report that it binds cardiolipin, the anionic phospholipid of the inner membrane required for cristae, and that the complex reduces cytochrome c peroxidase activity in their ischemia experiments. PubMed 23813215, DOI 10.1681/ASN.2012121216. That cardiolipin interaction is the mechanism to cite. It is not a tissue-repair slogan, and it is not a result for this lot.

Mitchell, Tamucci, Ng, and colleagues (eLife, 2022) published a structure-activity study of this tetrapeptide series. Use it when the question is which analogue does what in their assays. PubMed 35913044, DOI 10.7554/eLife.75531.

The catalog structure

The specification is D-Arg-Dmt-Lys-Phe-NH2, formula C32H49N9O5, mass about 639.8 g/mol. Dmt is dimethyltyrosine, which is the scavenger residue Zhao’s class depends on. Stereochemistry matters: the arginine is the D isomer in this table. A mass match that ignored stereochemistry would not separate this peptide from a diastereomer. The C-terminal amide is part of the mass. This peptide is not MOTS-c, which is sixteen residues and about 2174.6 g/mol.

How to verify this note

1. Open Birk 2013 and confirm the words SS-31 and cardiolipin. Open Zhao 2004 for the dimethyltyrosine class, and check the analogue codes in the full text.
2. Match CAS 736992-21-5, D-Arg-Dmt-Lys-Phe-NH2, and mass about 639.8 g/mol on the certificate.
3. Do not import a clinical endpoint from an elamipretide drug trial onto this research powder.

Selected References

Related Research Compounds

• MOTS-c
• MOTS-c + SS-31 Research Set
• NAD+ (Nicotinamide Adenine Dinucleotide)
• 5-Amino-1MQ
• AICAR
• SLU-PP-332
• Humanin

Research Use Only

For laboratory research use only. This product is not a drug, food, cosmetic or dietary supplement, is not FDA-approved, and is not intended for human or veterinary use or for the diagnosis, treatment, cure, mitigation or prevention of any disease. No dosing, administration or therapeutic information is provided. Sold only to qualified researchers; the purchaser is responsible for safe handling and compliance with all applicable laws and institutional requirements.