Molecular Structure Explorer
Livagen
Structure of the compound covered in this guide.
Last reviewed: October 2026 · Cleared Peptides research team
Research use only. Livagen (KEDA): Bioregulator Peptide Research Guide is supplied for laboratory research. It is not a drug, food, cosmetic, or dietary supplement. It is not FDA-approved. It is not for human or veterinary administration. This page does not give a dose or a method of administration. A study cited on this page describes that study’s own test article. It does not make this lot an approved medicine. To check a fact, open the PubMed or DOI link, confirm the authors and year, and match the paper’s compound name, CAS number, or sequence to the specification table. The full method is on the research desk page. Identity and purity for a lot are only what that lot’s certificate of analysis reports. An HPLC percentage is not a sterility result and not an endotoxin result unless the certificate prints those tests.
Livagen (Lys-Glu-Asp-Ala, KEDA) is a short synthetic peptide from the family of peptide bioregulators developed by V. Khavinson and colleagues, each modelled on peptide extracts from a particular tissue — for Livagen, liver.
Livagen is built on the Lys-Glu-Asp core shared by several bioregulators, with a C-terminal alanine; it is studied in chromatin and gene-expression research.
Livagen Structure and Identifiers
| Name | Livagen |
|---|---|
| Sequence | Lys-Glu-Asp-Ala (KEDA) |
| CAS number | Not available. A public CAS Registry Number has not been assigned to this sequence in the sources reviewed for this guide. |
| Molecular formula | C18H31N5O9 |
| Molecular weight | ≈461.5 g/mol |
| Tissue of research origin | Liver |
| Form | Lyophilized powder |
Short Peptide Bioregulators
Khavinson’s group proposed that di-, tri- and tetrapeptides derived from tissue extracts can enter cells and interact with DNA and histone proteins, influencing chromatin structure and tissue-specific gene expression. These peptides are studied mainly in cell-culture and molecular-modelling research. Read the peptide bioregulators overview.
Livagen and the Lys-Glu-Asp (KED) family
Many bioregulators share short sequence cores. Livagen belongs to the Lys-Glu-Asp (KED) family:
| Peptide | Sequence | Tissue of origin |
|---|---|---|
| Livagen | Lys-Glu-Asp-Ala | liver |
| Vesugen | Lys-Glu-Asp | blood vessels |
| Prostamax | Lys-Glu-Asp-Pro | prostate |
| Testagen | Lys-Glu-Asp-Gly | testes |
| Pancragen | Lys-Glu-Asp-Trp | pancreas |
This summary describes laboratory research only and makes no claim about effects in humans or animals.
Purity Testing and Storage
Every lot of Livagen supplied by Cleared Peptides is tested by an independent laboratory for identity and purity (or composition, for multi-component preparations), and the lot Certificate of Analysis is published on our COA page. Store lyophilized Livagen at −20 °C, sealed, dry and protected from light. Allow the vial to reach room temperature before opening. Handle according to your institution’s chemical-hygiene procedures.
Research materials referenced in this guide
Analytical testing notes for Livagen
Livagen is identified in this guide as CAS Not available. A public CAS Registry Number has not been assigned to this sequence in the sources reviewed for this guide., formula C18H31N5O9, listed mass ≈461.5 g/mol. The sequence recorded here is Lys-Glu-Asp-Ala (KEDA). An identity test compares a measurement with those values. A mass spectrum is the usual measurement for a peptide. FTIR, when a certificate uses it, is a supporting infrared fingerprint and is less specific for closely related sequences.
Livagen is a short peptide. Short, polar sequences retain weakly on C18 unless the mobile phase contains an ion-pairing acid such as trifluoroacetic acid. Detection is usually ultraviolet at 214 nm, because many of these sequences have no tryptophan or tyrosine and are nearly silent at 280 nm. Mass spectrometry, and MS/MS when isomers are plausible, is what distinguishes one short sequence from another with a similar retention time.
HPLC purity for this material is an area-percent result at the wavelength and gradient the laboratory states, commonly ultraviolet detection near 214 nm on a reversed-phase column. The instrument is a gradient pump, injector, column oven, and UV or diode-array detector. That percentage is not the number of milligrams in the vial. Water, acetate, trifluoroacetate, and other UV-silent material can dominate the gross weight while the purity figure stays high. Net peptide content, from an assay or amino-acid analysis, is the separate result to read when the certificate reports it.
A sterility test and an endotoxin test are not included in a chemical purity result. The compendial sterility test is a culture method (USP <71>): membrane filtration or direct inoculation into fluid thioglycollate medium and soybean-casein digest medium, incubated for 14 days. A PCR sterility screen uses a thermal cycler to detect microbial DNA and is a different method. The endotoxin test (USP <85> LAL, or USP <86> recombinant Factor C) reports endotoxin units with an incubating reader or a cartridge reader. Use a result only when that method is printed on the lot certificate. One published example in this catalog states that the report does not cover microbial contamination or endotoxins. The full description of equipment, standards, and how US laboratory accreditation works is in peptide analytical testing. Lot records are on the COA page.
Frequently Asked Questions
What is the sequence of Livagen?
Lys-Glu-Asp-Ala (KEDA); molecular formula C18H31N5O9, molecular weight ≈461.5 g/mol.
What tissue is Livagen associated with?
It was modelled on peptide extracts from liver.
Is Livagen for human use?
No. Cleared Peptides supplies Livagen for laboratory research use only; it is not for human or veterinary use.
Selected References
Peer-reviewed literature on the compounds discussed in this guide, listed as scientific background for laboratory researchers. Citation does not imply endorsement by the authors or any use other than in-vitro research.
- Lezhava T, et al. Activation of pericentromeric and telomeric heterochromatin in cultured lymphocytes from old individuals. Ann N Y Acad Sci. 2007;1100:387-99. PubMed 17460203 · DOI
- Khavinson VKh, et al. Effects of Livagen peptide on chromatin activation in lymphocytes from old people. Bull Exp Biol Med. 2002;134(4):389-92. PubMed 12533768 · DOI
- Khavinson VK. Tissue-specific effects of peptides. Bull Exp Biol Med. 2001;132(2):807-8. PubMed 11713572 · DOI
Laboratory note: solubility depends on salt form and solvent. This guide does not state a single solubility figure. Handling of lyophilized material is described in the peptide storage guide.
Research Use Only Notice
This guide is provided for educational and laboratory reference purposes. It summarizes published, primarily in-vitro and structural research literature and does not describe, recommend or imply any use in humans or animals. Products sold by Cleared Peptides are for laboratory research use only; they are not drugs, foods, cosmetics or dietary supplements, are not FDA-approved, and are not intended to diagnose, treat, cure, mitigate or prevent any disease. No dosing, administration or therapeutic information is provided.
